Just posted a new hit box guide for the Street Fighter series. Some moves have invincible frames or invulnerability, which means they have no Hittable Boxes for a short period of time.
Ken's Medium Punch Shoryuken is completely invulnerable in HD Remix during its start up period and the entire time he's traveling upwards. You can only hit him as he's coming down, when the blue hit boxes appear.
Just for comparison, let's check out Sagat's Hard Punch Tiger Uppercut. It offers a MUCH smaller window of invulnerability, and soon after the move is executed Sagat is vulnerable on the top of his head and from his waist on down.